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Patient Management

OPSUMIT® as standalone therapy offers patients the simplicity of once-daily dosing without titration.[1]

  • The recommended dosage of OPSUMIT® is 10 mg once daily for oral administration
  • No titration is necessary
  • Tablets can be administered with or without food
  • Tablets should not be split, crushed or chewed

OPSUMIT® has a well-established safety profile.[1][2] The majority of adverse events in the SERAPHIN study were mild to moderate.[2]

Most Frequent Adverse Events In The SERAPHIN Study[2]

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ALT, alanine aminotransferase; AST, aspartate aminotransferase; LFT, liver function test; PAH, pulmonary arterial hypertension; PDE-5i, phosphodiesterase type-5 inhibitor; ULN, upper limit of normal
*At baseline, 61.4% of SERAPHIN patients were receiving a PDE-5i and 5.4% were receiving oral or inhaled prostanoid as background therapy.

The overall incidence of treatment discontinuations due to adverse events with OPSUMIT® was similar to placebo (10.7% and 12.4%, respectively).[2]

For complete information about the safety and tolerability of OPSUMIT®, please consult the local Summary of Product Characteristics.

Learn More About OPSUMIT®

Studies

Details of the SERAPHIN study, where the safety and efficacy of OPSUMIT® were investigated in a Phase 3 study to assess the long-term benefits for pulmonary arterial hypertension (PAH) patients.

Guidelines

Details from the 2015 ESC/ERS guidelines to help you achieve and/or maintain a low-risk status for your patients with PAH.

References

Pulido T et al. N Engl J Med 2013; 369:809–818.
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